I use it/its in spaces where I do not plan on engaging with people as individuals, like on youtube where I get hundreds of comments and I’m not going to bother reading usernames.

I’m a little confused with this part. Are you referring to commenters using it/its or use it/its for yourself, but only on YouTube? I am a little put off by the second part, but I think I might be missing what you mean. Are you saying your replies on YouTube comments are going to be low effort interactions or that you aren’t considering the individuality of YouTube commentors at all? If the latter, that might lead to some pretty terrible interactions there. Not that YouTube comments are known for being good interactions, but I have seen channels be able to cultivate pretty positive comment sections. Being dismissive of folks might perpetuate bad behaviors and cultivate some pretty terrible attitudes.

I can see the benefit of setting expectations for interaction, but as someone that only uses one set of pronouns, I don’t think different ones in different spaces would work for me. Some other signifier might though.